CD8 helps TCR catch slippery self pMHC
A new model proposes that an applied force allows the co-receptor CD8 and the kinase Lck to selectively stabilize TCR interactions with negatively selecting ligands, but not those with positively selecting ligands, during the negative selection of self-reactive thymocytes.
| Principais autores: | , |
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| Formato: | Journal article |
| Publicado em: |
Springer Nature
2018
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| Resumo: | A new model proposes that an applied force allows the co-receptor CD8 and the kinase Lck to selectively stabilize TCR interactions with negatively selecting ligands, but not those with positively selecting ligands, during the negative selection of self-reactive thymocytes. |
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