CD8 helps TCR catch slippery self pMHC
A new model proposes that an applied force allows the co-receptor CD8 and the kinase Lck to selectively stabilize TCR interactions with negatively selecting ligands, but not those with positively selecting ligands, during the negative selection of self-reactive thymocytes.
| Main Authors: | , |
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| Format: | Journal article |
| Published: |
Springer Nature
2018
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| _version_ | 1797058318806548480 |
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| author | Dushek, O Dustin, M |
| author_facet | Dushek, O Dustin, M |
| author_sort | Dushek, O |
| collection | OXFORD |
| description | A new model proposes that an applied force allows the co-receptor CD8 and the kinase Lck to selectively stabilize TCR interactions with negatively selecting ligands, but not those with positively selecting ligands, during the negative selection of self-reactive thymocytes. |
| first_indexed | 2024-03-06T19:48:47Z |
| format | Journal article |
| id | oxford-uuid:2340d7ce-167b-437a-9415-ab6ddb3c423b |
| institution | University of Oxford |
| last_indexed | 2024-03-06T19:48:47Z |
| publishDate | 2018 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:2340d7ce-167b-437a-9415-ab6ddb3c423b2022-03-26T11:43:19ZCD8 helps TCR catch slippery self pMHCJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2340d7ce-167b-437a-9415-ab6ddb3c423bSymplectic Elements at OxfordSpringer Nature2018Dushek, ODustin, MA new model proposes that an applied force allows the co-receptor CD8 and the kinase Lck to selectively stabilize TCR interactions with negatively selecting ligands, but not those with positively selecting ligands, during the negative selection of self-reactive thymocytes. |
| spellingShingle | Dushek, O Dustin, M CD8 helps TCR catch slippery self pMHC |
| title | CD8 helps TCR catch slippery self pMHC |
| title_full | CD8 helps TCR catch slippery self pMHC |
| title_fullStr | CD8 helps TCR catch slippery self pMHC |
| title_full_unstemmed | CD8 helps TCR catch slippery self pMHC |
| title_short | CD8 helps TCR catch slippery self pMHC |
| title_sort | cd8 helps tcr catch slippery self pmhc |
| work_keys_str_mv | AT dusheko cd8helpstcrcatchslipperyselfpmhc AT dustinm cd8helpstcrcatchslipperyselfpmhc |