Interactome rewiring following pharmacological targeting of BET bromodomains

Targeting bromodomains (BRDs) of the bromo-and-extra-terminal (BET) family offers opportunities for therapeutic intervention in cancer and other diseases. Here, we profile the interactomes of BRD2, BRD3, BRD4, and BRDT following treatment with the pan-BET BRD inhibitor JQ1, revealing broad rewiring...

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Bibliographic Details
Main Authors:	Lambert, J-P, Picaud, SS, Fujisawa, T, Hou, H, Savitsky, P, Uusküla-Reimand, L, Gupta, G, Lin, ZY, Tucholska, M, Knight, JDR, Gonzalez-Badillo, B, St-Denis, N, Newman, JA, Stucki, M, Pelletier, L, Bandeira, N, Wilson, MD, Filippakopoulos, P, Gingras, AC
Format:	Journal article
Published:	Elsevier 2018

Interactome rewiring following pharmacological targeting of BET bromodomains

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