Mechanisms of antibody immunotherapy on clonal islet reactive T cells.

Clinical intervention trials evaluating the efficacy of antibody immunotherapy in type 1 diabetes are in progress. We tested effects on prediabetic islet antigen-specific autoreactive T cells of antithymocyte globulin (ATG) and humanized monoclonal antibodies against CD3 (ChAglyCD3) or CD25 (daclizu...

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Bibliographic Details
Main Authors: van de Linde, P, Tysma, O, Medema, J, Hale, G, Waldmann, H, Roelen, D, Roep, B
Format: Journal article
Language:English
Published: 2006