Functional significance of Na+/Ca2+ exchangers co-localization with ryanodine receptors.

Co-localization of Na+/Ca2+ exchangers (NCX) with ryanodine receptors (RyRs) is debated. We incorporate local NCX current in a biophysically detailed model of L-type Ca2+ channels (LCCs) and RyRs and study the effect of NCX on the regulation of Ca2+-induced Ca2+ release and the shape of the action p...

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Bibliographic Details
Main Authors: Sher, A, Hinch, R, Noble, P, Gavaghan, D, Noble, D
Format: Journal article
Language:English
Published: 2007