Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.

BACKGROUND AND PURPOSE: Carbonic anhydrase (CA) IX expression is increased upon hypoxia and has been proposed as a therapeutic target since it has been associated with poor prognosis, tumor progression and pH regulation. The aim of this study was to evaluate the antitumor activity of a high CAIX-af...

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Bibliographic Details
Main Authors: Dubois, L, Peeters, S, Lieuwes, N, Geusens, N, Thiry, A, Wigfield, S, Carta, F, McIntyre, A, Scozzafava, A, Dogné, J, Supuran, C, Harris, A, Masereel, B, Lambin, P
Format: Journal article
Language:English
Published: 2011