Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides.
Novel technological advances have improved our understanding of how cyclic nucleotides are able to convey signals faithfully between cellular compartments. Phosphodiesterases play a crucial role in shaping these signals in health and disease. The concept of compartmentalization is guiding the search...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Physiological Society
2014
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| _version_ | 1797058432401932288 |
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| author | Lomas, O Zaccolo, M |
| author_facet | Lomas, O Zaccolo, M |
| author_sort | Lomas, O |
| collection | OXFORD |
| description | Novel technological advances have improved our understanding of how cyclic nucleotides are able to convey signals faithfully between cellular compartments. Phosphodiesterases play a crucial role in shaping these signals in health and disease. The concept of compartmentalization is guiding the search for therapies that have the potential to offer greater efficacy and tolerability compared with current treatments. |
| first_indexed | 2024-03-06T19:50:28Z |
| format | Journal article |
| id | oxford-uuid:23cd614b-970e-48d3-a35e-3342a1ee66a7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:50:28Z |
| publishDate | 2014 |
| publisher | American Physiological Society |
| record_format | dspace |
| spelling | oxford-uuid:23cd614b-970e-48d3-a35e-3342a1ee66a72022-03-26T11:46:10ZPhosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:23cd614b-970e-48d3-a35e-3342a1ee66a7EnglishSymplectic Elements at OxfordAmerican Physiological Society2014Lomas, OZaccolo, MNovel technological advances have improved our understanding of how cyclic nucleotides are able to convey signals faithfully between cellular compartments. Phosphodiesterases play a crucial role in shaping these signals in health and disease. The concept of compartmentalization is guiding the search for therapies that have the potential to offer greater efficacy and tolerability compared with current treatments. |
| spellingShingle | Lomas, O Zaccolo, M Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides. |
| title | Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides. |
| title_full | Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides. |
| title_fullStr | Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides. |
| title_full_unstemmed | Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides. |
| title_short | Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides. |
| title_sort | phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides |
| work_keys_str_mv | AT lomaso phosphodiesterasesmaintainsignalingfidelityviacompartmentalizationofcyclicnucleotides AT zaccolom phosphodiesterasesmaintainsignalingfidelityviacompartmentalizationofcyclicnucleotides |