Defective insulin release machinery and insulin granule acidification in chloride channel 3null (ClC3(-/-)) mice

Eitemau Tebyg

• Regulated insulin release requires chloride channel 3 (ClC3) for proper granule acidification and priming
  gan: Li, D, et al.
  Cyhoeddwyd: (2005)
• Suppression of sulfonylurea- and glucose-induced insulin secretion in vitro and in vivo in mice lacking the chloride transport protein ClC-3.
  gan: Li, D, et al.
  Cyhoeddwyd: (2009)
• Priming of insulin granules for exocytosis by granular Cl(-) uptake and acidification.
  gan: Barg, S, et al.
  Cyhoeddwyd: (2001)
• Regulation of insulin granule exocytosis
  gan: Renström, E, et al.
  Cyhoeddwyd: (2008)
• CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cells.
  gan: Speidel, D, et al.
  Cyhoeddwyd: (2008)