Neutrophil elastase as a biomarker for bacterial infection in COPD

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is predominantly associated with neutrophilic inflammation. Active neutrophil elastase (NE) is a serine proteinase, secreted by neutrophils, in response to inflammation and pathogen invasion. We sought to investigate if NE could be used as a b...

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Bibliographic Details
Main Authors: Thulborn, S, Mistry, V, Brightling, C, Moffitt, K, Ribeiro, D, Bafadhel, M
Format: Journal article
Language:English
Published: BioMed Central 2019