Mutational analyses of the BbCRASP-1 protein of Borrelia burgdorferi identify residues relevant for the architecture and binding of host complement regulators FHL-1 and factor H.

Mutational analyses of the BbCRASP-1 protein of Borrelia burgdorferi identify residues relevant for the architecture and binding of host complement regulators FHL-1 and factor H.

Borrelia burgdorferi exploits multiple strategies to evade host immune responses. One central immune escape mechanism is the inactivation of the host complement attack by acquisition host complement regulators FHL-1 and factor H via complement regulator-acquiring surface proteins (BbCRASPs). The BbC...

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Bibliographic Details
Main Authors: Kraiczy, P, Hanssen-Hübner, C, Kitiratschky, V, Brenner, C, Besier, S, Brade, V, Simon, M, Skerka, C, Roversi, P, Lea, S, Stevenson, B, Wallich, R, Zipfel, P
Format: Journal article
Language:English
Published: 2009

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