Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo.

Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo.

BACKGROUND: The cationic lipid Genzyme lipid (GL) 67 is the current "gold-standard" for in vivo lung gene transfer. Here, we assessed, if GL67 mediated uptake of siRNAs and asODNs into airway epithelium in vivo. METHODS: Anti-lacZ and ENaC (epithelial sodium channel) siRNA and asODN were...

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Bibliographic Details
Main Authors: Griesenbach, U, Kitson, C, Escudero Garcia, S, Farley, R, Singh, C, Somerton, L, Painter, H, Smith, R, Gill, DR, Hyde, S, Chow, Y, Hu, J, Gray, M, Edbrooke, M, Ogilvie, V, MacGregor, G, Scheule, R, Cheng, S, Caplen, N, Alton, E
Format: Journal article
Language:English
Published: 2006

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