Inhibiting ex-vivo Th17 responses in Ankylosing Spondylitis by targeting Janus kinases

Treatment options for Ankylosing Spondylitis (AS) are still limited. The T helper cell 17 (Th17) pathway has emerged as a major driver of disease pathogenesis and a good treatment target. Janus kinases (JAK) are key transducers of cytokine signals in Th17 cells and therefore promising targets for th...

Full description

Bibliographic Details
Main Authors: Hammitzsch, A, Chen, L, de Wit, J, Al-Mossawi, H, Ridley, A, Sekine, T, Simone, D, Doig, K, Skapenko, A, Bowness, P
Format: Journal article
Published: Springer Nature 2018