Modular isoquinoline synthesis using catalytic enolate arylation and in situ functionalization.
A methyl ketone, an aryl bromide, an electrophile, and ammonium chloride were combined in a four-component, three-step, and one-pot coupling procedure to furnish substituted isoquinolines in overall yields of up to 80%. This protocol utilizes the palladium catalyzed α-arylation reaction of an enolat...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2013
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