Disruption of tumour-host communication by downregulation of LFA-1 reduces COX-2 and e-NOS expression and inhibits brain metastasis growth

Over 20% of cancer patients will suffer metastatic spread to the brain, and prognosis remains poor. Communication between tumour cells and host tissue is essential during metastasis, yet little is known of the processes underlying such interactions in the brain. Here we tes...

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Bibliographic Details
Main Authors: Sarmiento Soto, M, O'Brien, E, Andreou, K, Scrace, S, Zakaria, R, Jenkinson, M, O'Neill, E, Sibson, N
Format: Journal article
Published: Impact Journals 2016