Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice.

Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice.

This study investigated the function of each of the hypoxia inducible factor (HIF) prolyl-4-hydroxylase enzymes (PHD1–3) in the first 24 h following transient focal cerebral ischaemia by using mice with each isoform genetically suppressed. Male, 8- to 12-week old PHD1−/−, PHD2+/− and PHD3−/− mice an...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Chen, R, Nagel, S, Papadakis, M, Bishop, T, Pollard, P, Ratcliffe, P, Pugh, C, Buchan, A
التنسيق:	Journal article
اللغة:	English
منشور في:	2012

مواد مشابهة

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.
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Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation.
حسب: Tian, Y, وآخرون
منشور في: (2006)

Regulation of HIF: prolyl hydroxylases.
حسب: Stolze, I, وآخرون
منشور في: (2006)

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
حسب: Tuckerman, JR, وآخرون
منشور في: (2004)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
حسب: Mole, D, وآخرون
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The use of dioxygen by HIF prolyl hydroxylase (PHD1).
حسب: McNeill, L, وآخرون
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Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
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The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha.
حسب: Willam, C, وآخرون
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Prolyl hydroxylases and therapeutics.
حسب: Smith, T, وآخرون
منشور في: (2010)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
حسب: Chan, M, وآخرون
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Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats.
حسب: Nagel, S, وآخرون
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Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats
حسب: Nagel, S, وآخرون
منشور في: (2011)

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
حسب: Hewitson, K, وآخرون
منشور في: (2007)

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
حسب: Masson, N, وآخرون
منشور في: (2003)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
حسب: Chowdhury, R, وآخرون
منشور في: (2016)

Differential prolyl hydroxylation by six Physcomitrella prolyl-4 hydroxylases
حسب: Christine Rempfer, وآخرون
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Substrate selectivity of prolyl hydroxylases
حسب: McDonough, M
منشور في: (2018)

Hyperplasia of pulmonary neuroepithelial bodies (NEB) in lungs of prolyl hydroxylase -1(PHD-1) deficient mice
حسب: Pan, J, وآخرون
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Hyperplasia of pulmonary neuroepithelial bodies (NEB) in lungs of prolyl hydroxylase -1(PHD-1) deficient mice.
حسب: Pan, J, وآخرون
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Hyperplasia of Pulmonary Neuroepithelial Bodies (NEB) in Lungs of Prolyl Hydroxylase-1(PHD-1) Deficient Mice
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The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin.
حسب: Masson, N, وآخرون
منشور في: (2004)

Suppression of the inflammatory response by diphenyleneiodonium after transient focal cerebral ischemia.
حسب: Nagel, S, وآخرون
منشور في: (2012)

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
حسب: Yeh, TL, وآخرون
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Structural and mechanistic studies on prolyl hydroxylases
حسب: Chowdhury, R
منشور في: (2008)

Inhibition of a viral prolyl hydroxylase
حسب: Langley, G, وآخرون
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Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model
حسب: Singh, A, وآخرون
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HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
حسب: Willam, C, وآخرون
منشور في: (2006)

Hyperplasia and hypertrophy of pulmonary neuroepithelial bodies, presumed airway hypoxia sensors, in hypoxia-inducible factor prolyl hydroxylase-deficient mice.
حسب: Ratcliffe, P, وآخرون
منشور في: (2016)

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.
حسب: Appelhoff, R, وآخرون
منشور في: (2004)

Microarray analysis of the global gene expression profile following hypothermia and transient focal cerebral ischemia.
حسب: Nagel, S, وآخرون
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Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
حسب: Chowdhury, R, وآخرون
منشور في: (2013)

Structural, functional and evolutionary studies on prolyl-hydroxylases
حسب: Scotti, J
منشور في: (2014)

Iron homeostasis and its interaction with prolyl hydroxylases.
حسب: Mole, D
منشور في: (2010)

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.
حسب: Walmsley, SR, وآخرون
منشور في: (2011)

Potent and selective triazole-based inhibitors of the hypoxia-inducible factor prolyl-hydroxylases with activity in the murine brain
حسب: Chan, MC, وآخرون
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Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses
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