Probing novel epitopes on the Plasmodium falciparum circumsporozoite protein for vaccine development

RTS,S and R21 are the only vaccines recommended by the WHO to protect children from Plasmodium falciparum (Pf) clinical malaria. Both vaccines target the Pf sporozoite surface protein circumsporozoite protein (CSP). Recent studies showed that human antibodies neutralize Pf sporozoites most efficient...

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Autors principals: Krenger, PS, Roques, M, Vogt, AS, Pardini, A, Rothen, DA, Balke, I, Schnider, ST, Mohsen, MO, Heussler, VT, Zeltins, A, Bachmann, MF
Format: Journal article
Idioma:English
Publicat: Nature Research 2024