SCL/TAL1: a multifaceted regulator from blood development to disease

SCL/TAL1: a multifaceted regulator from blood development to disease

SCL/TAL1 (stem cell leukemia/T-cell acute lymphoblastic leukemia [T-ALL] 1) is an essential transcription factor in normal and malignant hematopoiesis. It is required for specification of the blood program during development, adult hematopoietic stem cell survival and quiescence, and terminal matura...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Porcher, C, Chagraoui, H, Kristiansen, M
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	American Society of Hematology 2017

Eitemau Tebyg

Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis.
gan: Kassouf, M, et al.
Cyhoeddwyd: (2008)

SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells
gan: Chagraoui, H, et al.
Cyhoeddwyd: (2018)

SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells
gan: Hedia Chagraoui, et al.
Cyhoeddwyd: (2018-12-01)

Establishing the transcriptional programme for blood: Transcriptional regulation of the SCL/TAL-1 gene.
gan: Gottgens, B, et al.
Cyhoeddwyd: (2003)

Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1.
gan: Schlaeger, T, et al.
Cyhoeddwyd: (2004)

SCL establishes a transcriptional and epigenetic repressive environment in blood-fated cells to suppress alternative mesodermal lineages
gan: Porcher, C, et al.
Cyhoeddwyd: (2016)

The oncoprotein SCL/Tal-1 associates with the co-repressor ETO-2 in multiprotein complexes in erythroid cells and megalkaryocytes.
gan: Schuh, A, et al.
Cyhoeddwyd: (2004)

Characterisation of SCL DNA-binding functions in vivo in haematopoiesis.
gan: Kassouf, M, et al.
Cyhoeddwyd: (2005)

The bHLH protein SCL/Tal-l interacts with the co-repressor ETO-2 in erythroid cells and megakaryocytes.
gan: Schuh, A, et al.
Cyhoeddwyd: (2005)

Discovering Regulatory SNPs by Genome-Wide Analysis of Differential Scl/TAL-1 Occupancy in Human Primary Erythroid Cells
gan: De Gobbi, M, et al.
Cyhoeddwyd: (2011)

SCL-mediated regulation of the cell-cycle regulator p21 is critical for murine megakaryopoiesis.
gan: Chagraoui, H, et al.
Cyhoeddwyd: (2011)

Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver.
gan: Landry, JR, et al.
Cyhoeddwyd: (2008)

Molecular dissection of SCL helix-loop-helix domain.
gan: Schlaeger, T, et al.
Cyhoeddwyd: (2003)

Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1.
gan: Gering, M, et al.
Cyhoeddwyd: (2003)

The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1.
gan: Lécuyer, E, et al.
Cyhoeddwyd: (2002)

Role of Tal1 in murine blood vessel development
gan: Fritzsche, M
Cyhoeddwyd: (2015)

Regulatory factor X‐5/SCL/TAL1 interruption site axis promotes aerobic glycolysis and hepatocellular carcinoma cell stemness
gan: Zhi‐Zhong Zhang, et al.
Cyhoeddwyd: (2025-01-01)

The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin - SCL/TAL1 - CD44 axis
gan: Parimala Sonika Godavarthy, et al.
Cyhoeddwyd: (2020-01-01)

Establishment of an ES cell-derived murine megakaryocytic cell line, MKD1, with features of primary megakaryocyte progenitors.
gan: Chagraoui, H, et al.
Cyhoeddwyd: (2012)

Identification of critical residues for the function of the bHLH transcription factor SCL in hematopoietic stem cells.
gan: Porcher, C, et al.
Cyhoeddwyd: (2003)

Establishment of an ES cell-derived murine megakaryocytic cell line, MKD1, with features of primary megakaryocyte progenitors.
gan: Hedia Chagraoui, et al.
Cyhoeddwyd: (2012-01-01)

Dioramas SCL2110
gan: Rodrigo Tisi
Cyhoeddwyd: (2012-04-01)

Scl is required for dorsal aorta as well as blood formation in zebrafish embryos.
gan: Patterson, L, et al.
Cyhoeddwyd: (2005)

Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells.
gan: Kassouf, M, et al.
Cyhoeddwyd: (2010)

The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity.
gan: Pimanda, J, et al.
Cyhoeddwyd: (2007)

Fibroblast growth factor controls the timing of Scl, Lmo2, and Runx1 expression during embryonic blood development.
gan: Walmsley, M, et al.
Cyhoeddwyd: (2008)

ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis.
gan: Schuh, A, et al.
Cyhoeddwyd: (2005)

Role of the haematopoietic transcription factor SCL in mesoderm development
gan: Green, A
Cyhoeddwyd: (2012)

1700-tal
gan: Gunnar Broberg, et al.
Cyhoeddwyd: (2008-01-01)

THE IMPACT OF NEW NORMAL REGULATION TO THE IMPLEMENTATION OF SCL APPROACH IN SECONDARY LEVEL
gan: Akrim Akrim, et al.
Cyhoeddwyd: (2020-12-01)

The Splicing Factor OsSCL26 Regulates Phosphorus Homeostasis in Rice
gan: Shanshan Lu, et al.
Cyhoeddwyd: (2023-06-01)

Regulation of the stem cell leukemia (SCL) gene: a tale of two fishes.
gan: Barton, L, et al.
Cyhoeddwyd: (2001)

ToTAL1y degraded - rapid dTAG proteolysis of TAL1 in T-cell acute lymphoblastic leukemia
gan: Joana R. Costa, et al.
Cyhoeddwyd: (2023-12-01)

Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors.
gan: Göttgens, B, et al.
Cyhoeddwyd: (2002)

Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer.
gan: Nottingham, W, et al.
Cyhoeddwyd: (2007)

Higiensko čiščenje tal
gan: Bronka Brzin
Cyhoeddwyd: (1973-06-01)

Tal como somos
gan: Carlos J. Irisarri
Cyhoeddwyd: (2021-11-01)

Dego's disease in a female child with Anti-Scl-70 antibody positivity
gan: Jigna Krunal Padhiyar, et al.
Cyhoeddwyd: (2018-01-01)

Identifying a novel role for the master regulator Tal1 in the Endothelial to Hematopoietic Transition
gan: Yasmin Natalia Serina Secanechia, et al.
Cyhoeddwyd: (2022-10-01)

Tal Pai, Tal Filho? Decisões coletivas tendo em conta relações familiares
gan: Ariádne Scalfoni Rigo, et al.
Cyhoeddwyd: (2018-01-01)