Identification of histone peptide binding specificity and small-molecule ligands for the TRIM33α and TRIM33β bromodomains

TRIM33 is a member of the tripartite motif (TRIM) family of proteins, some of which possess E3 ligase activity and are involved in the ubiquitin-dependent degradation of proteins. Four of the TRIM family proteins, TRIM24 (TIF1α), TRIM28 (TIF1β), TRIM33 (TIF1γ) and TRIM66, contain C-terminal plant ho...

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Main Authors: Sekirnik, AR, Reynolds, JK, See, L, Bluck, JP, Scorah, AR, Tallant, C, Lee, B, Leszczynska, KB, Grimley, RL, Storer, RI, Malattia, M, Crespillo, S, Caria, S, Duclos, S, Hammond, EM, Knapp, S, Morris, GM, Duarte, F, Biggin, PC, Conway, SJ
Format: Journal article
Language:English
Published: American Chemical Society 2022