Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium falciparum malaria parasites has led to widespread treatment failures across Southeast Asia. In Africa, K13-propeller genotyping confirms the emergence of the R561H mutation in Rwanda and highlights the continuing domina...

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Main Authors:	Stokes, BH, Dhingra, SK, Rubiano, K, Mok, S, Straimer, J, Gnädig, NF, Deni, I, Schindler, KA, Bath, JR, Ward, KE, Striepen, J, Yeo, T, Ross, LS, Legrand, E, Ariey, F, Cunningham, CH, Souleymane, IM, Gansané, A, Nzoumbou-Boko, R, Ndayikunda, C, Kabanywanyi, AM, Uwimana, A, Smith, SJ, Kolley, O, Ndounga, M, Warsame, M, Leang, R, Nosten, F, Anderson, TJ, Rosenthal, PJ, Ménard, D, Fidock, DA
Format:	Journal article
Language:	English
Published:	eLife Sciences Publications 2021

Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

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