Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium falciparum malaria parasites has led to widespread treatment failures across Southeast Asia. In Africa, K13-propeller genotyping confirms the emergence of the R561H mutation in Rwanda and highlights the continuing domina...

Bibliografiset tiedot
Päätekijät:	Stokes, BH, Dhingra, SK, Rubiano, K, Mok, S, Straimer, J, Gnädig, NF, Deni, I, Schindler, KA, Bath, JR, Ward, KE, Striepen, J, Yeo, T, Ross, LS, Legrand, E, Ariey, F, Cunningham, CH, Souleymane, IM, Gansané, A, Nzoumbou-Boko, R, Ndayikunda, C, Kabanywanyi, AM, Uwimana, A, Smith, SJ, Kolley, O, Ndounga, M, Warsame, M, Leang, R, Nosten, F, Anderson, TJ, Rosenthal, PJ, Ménard, D, Fidock, DA
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	eLife Sciences Publications 2021

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