N‐phenyl‐1,2,3,4‐tetrahydroisoquinoline:an alternative scaffold for design of 17β‐hydroxysteroid dehydrogenase 1 inhibitors

N‐phenyl‐1,2,3,4‐tetrahydroisoquinoline:an alternative scaffold for design of 17β‐hydroxysteroid dehydrogenase 1 inhibitors

17β‐Hydroxysteroid dehydrogenases act at the pre‐receptor level, catalysing interconversion at the C17 position between oxidized and reduced forms of steroidal nuclear receptor ligands. The type 1 enzyme, expressed in malignant cells, catalyses reduction of the less active estrone to estradiol and i...

書誌詳細
主要な著者:	Mottinelli, M, Sinreh, M, Rižner, TL, Leese, MP, Potter, BVL
フォーマット:	Journal article
言語:	English
出版事項:	Wiley 2020

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