N‐phenyl‐1,2,3,4‐tetrahydroisoquinoline:an alternative scaffold for design of 17β‐hydroxysteroid dehydrogenase 1 inhibitors

17β‐Hydroxysteroid dehydrogenases act at the pre‐receptor level, catalysing interconversion at the C17 position between oxidized and reduced forms of steroidal nuclear receptor ligands. The type 1 enzyme, expressed in malignant cells, catalyses reduction of the less active estrone to estradiol and i...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Mottinelli, M, Sinreh, M, Rižner, TL, Leese, MP, Potter, BVL
Fformat: Journal article
Iaith:English
Cyhoeddwyd: Wiley 2020