Natural killer T cells accelerate atherogenesis in mice

We have investigated the potential role of CD1d-restricted natural killer T (NKT) cells in the development of atherosclerosis in mice. When fed an atherogenic diet (AD), NKT cell-deficient CD1d-/- mice had significantly smaller atherosclerotic lesions than AD-fed C57BL/6 (wild-type [WT]) mice. A sig...

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Bibliographic Details
Main Authors: Nakai, Y, Iwabuchi, K, Fujii, S, Ishimori, N, Dashtsoodol, N, Watano, K, Mishima, T, Iwabuchi, C, Tanaka, S, Bezbradica, J, Nakayama, T, Taniguchi, M, Miyake, S, Yamamura, T, Kitabatake, A, Joyce, S, Van Kaer, L, Onoé, K
Format: Journal article
Language:English
Published: American Society of Hematology 2004