Blockade of oncogenic NOTCH1 with the SERCA inhibitor CAD204520 in T cell acute lymphoblastic leukemia

The identification of SERCA (sarco/endoplasmic reticulum calcium ATPase) as a target for modulating gain-of-function NOTCH1 mutations in Notch-dependent cancers has spurred the development of this compound class for cancer therapeutics. Despite the innate toxicity challenge associated with SERCA inh...

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Bibliographic Details
Main Authors:	Marchesini, M, Gherli, A, Montanaro, A, Patrizi, L, Sorrentino, C, Pagliaro, L, Rompietti, C, Kitara, S, Heit, S, Olesen, CE, Møller, JV, Savi, M, Bocchi, L, Vilella, R, Rizzi, F, Baglione, M, Rastelli, G, Loiacono, C, La Starza, R, Mecucci, C, Stegmaier, K, Aversa, F, Stilli, D, Lund Winther, A-M, Sportoletti, P, Bublitz, M, Dalby-Brown, W, Roti, G
Format:	Journal article
Language:	English
Published:	Cell Press 2020

Blockade of oncogenic NOTCH1 with the SERCA inhibitor CAD204520 in T cell acute lymphoblastic leukemia

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