A novel domain suggests a ciliary function for ASPM, a brain size determining gene.

A novel domain suggests a ciliary function for ASPM, a brain size determining gene.

Show other versions (1)

The N-terminal domain of abnormal spindle-like microcephaly-associated protein (ASPM) is identified as a member of a novel family of ASH (ASPM, SPD-2, Hydin) domains. These domains are present in proteins associated with cilia, flagella, the centrosome and the Golgi complex, and in Hydin and OCRL wh...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Ponting, C
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2006

Eitemau Tebyg

A novel domain suggests a ciliary function for ASPM, a brain size determining gene
gan: Ponting, C
Cyhoeddwyd: (2006)

Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion.
gan: Natalay Kouprina, et al.
Cyhoeddwyd: (2004-05-01)

Microcephaly: tracing the evolutionary lineage of ASPM gene.
gan: Mushtaq Hussain, et al.
Cyhoeddwyd: (2010-08-01)

Microcephaly: tracing the evolutionary lineage of ASPM gene.
gan: Mushtaq Hussain, et al.
Cyhoeddwyd: (2010-08-01)

The Multiple Mitotic Roles of the ASPM Orthologous Proteins: Insight into the Etiology of ASPM-Dependent Microcephaly
gan: Alyona V. Razuvaeva, et al.
Cyhoeddwyd: (2023-03-01)

ASPM and the evolution of cerebral cortical size in a community of New World monkeys.
gan: Fernando A Villanea, et al.
Cyhoeddwyd: (2012-01-01)

A novel splice-site mutation in the ASPM gene underlies autosomal recessive primary microcephaly
gan: Jamil A. Hashmi, et al.
Cyhoeddwyd: (2016-11-01)

Novel Pathogenic Mutation Mapping of ASPM Gene in Consanguineous Pakistani Families with Primary Microcephaly
gan: T. Batool, et al.
Cyhoeddwyd: (2021-08-01)

The derived allele of ASPM is associated with lexical tone perception.
gan: Patrick C M Wong, et al.
Cyhoeddwyd: (2012-01-01)

A Novel Frameshift Mutation in Abnormal Spindle-Like Microcephaly (ASPM) Gene in an Iranian Patient with Primary Microcephaly: A Case Report
gan: Afsaneh BAZGIR, et al.
Cyhoeddwyd: (2019-11-01)

Human ASPM participates in spindle organisation, spindle orientation and cytokinesis
gan: Woods C Geoffrey, et al.
Cyhoeddwyd: (2010-11-01)

Whole Exome Sequencing Identifies Three Novel Mutations in the ASPM Gene From Saudi Families Leading to Primary Microcephaly
gan: Muhammad Imran Naseer, et al.
Cyhoeddwyd: (2021-02-01)

Importance and application of WES in fetal genetic diagnostics: Identification of novel ASPM mutation in a fetus with microcephaly
gan: Renata Szalai, et al.
Cyhoeddwyd: (2024-03-01)

Microcephaly primary hereditary (MCPH): Report of novel ASPM variants and prenatal diagnosis in a Vietnamese family
gan: Thinh Huy Tran, et al.
Cyhoeddwyd: (2021-09-01)

Neuroblastoma with high ASPM reveals pronounced heterogeneity and poor prognosis
gan: Chao Li, et al.
Cyhoeddwyd: (2024-09-01)

Expression of ASPM in Lung Adenocarcinoma and Its Relationship with Development and Prognosis
gan: Junjie WANG, et al.
Cyhoeddwyd: (2020-01-01)

ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells
gan: Tze‐Sian Chan, et al.
Cyhoeddwyd: (2024-03-01)

ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules
gan: Gai, M, et al.
Cyhoeddwyd: (2016)

Correction: Neuroblastoma with high ASPM reveals pronounced heterogeneity and poor prognosis
gan: Chao Li, et al.
Cyhoeddwyd: (2024-10-01)

Implementation Framework for Robust Detection, Synchronization, and Decoding of M-ASPM Communications
gan: Alexei V. Nikitin, et al.
Cyhoeddwyd: (2024-01-01)

The neurological and non-neurological roles of the primary microcephaly-associated protein ASPM
gan: Xingxuan Wu, et al.
Cyhoeddwyd: (2023-08-01)

Deregulation of microcephalin and ASPM expression are correlated with epithelial ovarian cancer progression.
gan: Rawiah Alsiary, et al.
Cyhoeddwyd: (2014-01-01)

RETRACTED: ASPM predicts poor prognosis and regulates cell proliferation in bladder cancer
gan: Zhen‐Ya Gao, et al.
Cyhoeddwyd: (2020-12-01)

Identification of a wide spectrum of ciliary gene mutations in nonsyndromic biliary atresia patients implicates ciliary dysfunction as a novel disease mechanism
gan: Wai-Yee Lam, et al.
Cyhoeddwyd: (2021-09-01)

Screening ANLN and ASPM as bladder urothelial carcinoma-related biomarkers based on weighted gene co-expression network analysis
gan: Tenghao Yang, et al.
Cyhoeddwyd: (2023-03-01)

The microtubule-associated protein ASPM regulates spindle assembly and meiotic progression in mouse oocytes.
gan: Xiao-Ling Xu, et al.
Cyhoeddwyd: (2012-01-01)

ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability
gan: Shibin Xu, et al.
Cyhoeddwyd: (2021-06-01)

ASPM May be Related to the Malignant Progression of Hepatitis B and is Associated With a Poor Prognosis of Hepatocellular Carcinoma
gan: Siyou Tan, et al.
Cyhoeddwyd: (2022-03-01)

Evaluation of ciliary functions and ciliary beat frequency via cell culture method in patients with primary ciliary dyskinesia
gan: Nagehan Emiralioğlu, et al.
Cyhoeddwyd: (2022-08-01)

Novel domains and orthologues of eukaryotic transcription elongation factors.
gan: Ponting, C
Cyhoeddwyd: (2002)

Ciliary genes are down-regulated in bronchial tissue of primary ciliary dyskinesia patients.
gan: Maciej Geremek, et al.
Cyhoeddwyd: (2014-01-01)

Gene expression and functional annotation of the human ciliary body epithelia.
gan: Sarah F Janssen, et al.
Cyhoeddwyd: (2012-01-01)

Novel function of a primary ciliary dyskinesia-associated protein in myeloid cells
Cyhoeddwyd: (2021-05-01)

Tone and genes: New cross-linguistic data and methods support the weak negative effect of the "derived" allele of ASPM on tone, but not of Microcephalin.
gan: Dan Dediu
Cyhoeddwyd: (2021-01-01)

Ciliary body size in chronic angle-closure glaucoma
gan: Jost B. Jonas, et al.
Cyhoeddwyd: (2023-10-01)

Localization of a guanylyl cyclase to chemosensory cilia requires the novel ciliary MYND domain protein DAF-25.
gan: Victor L Jensen, et al.
Cyhoeddwyd: (2010-11-01)

ASPM Promotes the Progression of Anaplastic Thyroid Carcinomas by Regulating the Wnt/β-Catenin Signaling Pathway
gan: Liang Jiang, et al.
Cyhoeddwyd: (2022-01-01)

Loss of Aspm causes increased apoptosis of developing neural cells during mouse cerebral corticogenesis
gan: Madoka Tonosaki, et al.
Cyhoeddwyd: (2023-01-01)

Evidence for impaired olfactory function and structural brain integrity in a disorder of ciliary function, Usher syndrome
gan: João Nuno Ramos, et al.
Cyhoeddwyd: (2019-01-01)

Whole exome sequencing identifies a novel homozygous frameshift mutation in the ASPM gene, which causes microcephaly 5, primary, autosomal recessive [version 1; referees: 2 approved]
gan: Desaraju Suresh Bhargav, et al.
Cyhoeddwyd: (2017-12-01)