Tel1/ETV6 specifies blood stem cells through the agency of VEGF signaling.

Tel1/ETV6 specifies blood stem cells through the agency of VEGF signaling.

The regulation of stem cell ontogeny is poorly understood. We show that the leukemia-associated Ets transcription factor, Tel1/ETV6, specifies the first hematopoietic stem cells (HSCs) in the dorsal aorta (DA). In contrast, Tel1/ETV6 has little effect on embryonic blood formation, further distinguis...

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Dettagli Bibliografici
Autori principali:	Ciau-Uitz, A, Pinheiro, P, Gupta, R, Enver, T, Patient, R
Natura:	Journal article
Lingua:	English
Pubblicazione:	2010

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