Strategies for the construction of morphinan alkaloid AB-rings: regioselective Friedel-Crafts-type cyclisations of gamma-aryl-beta-benzoylamido acids with asymmetrically substituted gamma-aryl rings
The regioselectivity of the Friedel-Crafts-type cyclisation of a range of γ-aryl-β-benzoylamido acids, bearing oxy substituents at the C(3)- and C(4)-positions of the γ-aryl ring, has been investigated. In all of the cases examined (with 3,4-dimethoxy, 3,4-methylenedioxy and 3-hydroxy-4-methoxy subs...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Published: |
Elsevier
2016
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