Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.

The DDR1 receptor tyrosine kinase is activated by matrix collagens and has been implicated in numerous cellular functions such as proliferation, differentiation, adhesion, migration, and invasion. Here we report the discovery of a potent and selective DDR1 inhibitor, DDR1-IN-1, and present the 2.2 Å...

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Detaylı Bibliyografya
Asıl Yazarlar: Kim, H, Tan, L, Weisberg, E, Liu, F, Canning, P, Choi, H, Ezell, SA, Wu, H, Zhao, Z, Wang, J, Mandinova, A, Griffin, J, Bullock, A, Liu, Q, Lee, S, Gray, N
Materyal Türü: Journal article
Dil:English
Baskı/Yayın Bilgisi: 2013