Opposite malaria and pregnancy effect on oral bioavailability of artesunate - a population pharmacokinetic evaluation.

The aim was to compare the pharmacokinetic properties of artesunate and dihydroartemisinin in the same women: i) pregnant with acute uncomplicated malaria on day 1 and 2, ii) pregnant with convalescent malaria on day 7 and iii) in a healthy state 3 months post-partum on day 1, 2 and 7.Non-linear mix...

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Bibliographic Details
Main Authors: Kloprogge, F, McGready, R, Phyo, A, Rijken, M, Hanpithakpon, W, Than, H, Hlaing, N, Zin, N, Day, N, White, N, Nosten, F, Tarning, J
Format: Journal article
Language:English
Published: Wiley 2015