Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis.

BACKGROUND: Asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of endothelial nitric oxide synthase (eNOS), is considered to be a risk factor for atherosclerosis. However, the mechanisms relating ADMA with vascular function have been evaluated in vitro and in animal models, but its effec...

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Main Authors: Antoniades, C, Shirodaria, C, Leeson, P, Antonopoulos, A, Warrick, N, Van-Assche, T, Cunnington, C, Tousoulis, D, Pillai, R, Ratnatunga, C, Stefanadis, C, Channon, K
Format: Journal article
Language:English
Published: 2009