Cutting Edge: The Ontogeny and Function of Va14Ja18 Natural T Lymphocytes Require Signal Processing by Protein Kinase Cθ and NF-κB

The rapid and robust immunoregulatory cytokine response of Va14Ja18 natural T (iNKT) cells to glycolipid Ags determines their diverse functions. Unlike conventional T cells, iNKT lymphocyte ontogeny absolutely requires NF-kappa B signaling. However, the precise role of NF-kappa B in iNKT cell functi...

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Main Authors: Stanic, AK, Bezbradica, JS, Park, J-J, Van Kaer, L, Boothby, MR, Joyce, S
格式: Journal article
语言:English
出版: American Association of Immunologists 2004