Structure based biophysical characterization of the PROPPIN Atg18 shows Atg18 oligomerization upon membrane binding
PROPPINs (β-propellers that bind polyphosphoinositides) are PtdIns3P and PtdIns(3,5)P2 binding autophagy related proteins. They contain two phosphatidylinositolphosphate (PIP) binding sites and a conserved FRRG motif is essential for PIP binding. Here we present the 2.0 Å resolution crystal structur...
| Hauptverfasser: | , , , , , |
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| Format: | Journal article |
| Sprache: | English |
| Veröffentlicht: |
Nature Research
2018
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