Trastuzumab-resistant breast cancer cells remain sensitive to the auger electron-emitting radiotherapeutic agent 111In-NLS-trastuzumab and are radiosensitized by methotrexate.

UNLABELLED: Our goals in this study were to determine whether (111)In-trastuzumab coupled to peptides harboring nuclear localizing sequences (NLSs) could kill trastuzumab-resistant breast cancer cell lines through the emission of Auger electrons and whether the combination of radiosensitization with...

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मुख्य लेखकों: Costantini, D, Bateman, K, McLarty, K, Vallis, K, Reilly, R
स्वरूप: Journal article
भाषा:English
प्रकाशित: 2008