Studies on the inhibition of human hypoxia inducible factor (HIF) hydroxylases

<p>Hypoxia inducible factor (HIF) is an α/β-heterodimeric transcription factor that regulates cellular responses to hypoxia in metazoans. The activity and stability of the HIF-α subunits are regulated by prolyl and asparaginyl hydroxylation. Human HIF-1α prolyl hydroxylation occurs at Pro402 a...

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Chi tiết về thư mục
Tác giả chính: Yeoh, KK
Tác giả khác: Schofiled, CJ
Định dạng: Luận văn
Ngôn ngữ:English
Được phát hành: 2012
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