Studies on the inhibition of human hypoxia inducible factor (HIF) hydroxylases

Studies on the inhibition of human hypoxia inducible factor (HIF) hydroxylases

<p>Hypoxia inducible factor (HIF) is an α/β-heterodimeric transcription factor that regulates cellular responses to hypoxia in metazoans. The activity and stability of the HIF-α subunits are regulated by prolyl and asparaginyl hydroxylation. Human HIF-1α prolyl hydroxylation occurs at Pro402 a...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Yeoh, KK
Awduron Eraill:	Schofiled, CJ
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2012
Pynciau:	Biochemistry

Eitemau Tebyg

Inhibition of hypoxia inducible factor (HIF) hydroxylases
gan: Conejo-Garcia, A, et al.
Cyhoeddwyd: (2005)

Inhibition studies on hypoxia-inducible factor (HIF) hydroxylases
gan: Chan, M
Cyhoeddwyd: (2014)

Studies on HIF hydroxylases
gan: Webb, J
Cyhoeddwyd: (2008)

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.
gan: Webb, J, et al.
Cyhoeddwyd: (2009)

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
gan: Flashman, E, et al.
Cyhoeddwyd: (2010)

Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
gan: Lippl, K
Cyhoeddwyd: (2018)

Signalling hypoxia by HIF hydroxylases.
gan: Schofield, C, et al.
Cyhoeddwyd: (2005)

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
gan: Hewitson, K, et al.
Cyhoeddwyd: (2002)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
gan: Chowdhury, R, et al.
Cyhoeddwyd: (2013)

Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?
gan: Moritz J. Strowitzki, et al.
Cyhoeddwyd: (2019-04-01)

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
gan: Cockman, M, et al.
Cyhoeddwyd: (2006)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
gan: Chan, M, et al.
Cyhoeddwyd: (2016)

Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
gan: Maria Savyuk, et al.
Cyhoeddwyd: (2020-07-01)

Structural, functional and evolutionary studies on prolyl-hydroxylases
gan: Scotti, J
Cyhoeddwyd: (2014)

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].
gan: Stolze, I, et al.
Cyhoeddwyd: (2004)

Kinetic investigations of the oxygen entry pathway of the hypoxia-inducible factor (HIF) prolyl hydroxylase 2
gan: Kearney, L
Cyhoeddwyd: (2015)

Synthesis And Characterization Of Potential Human Hypoxia Inducible Factor (Hif) Prolyl Hydroxylase Domain 2 (Phd-2) Inhibitors
gan: Toh, Lee Roy
Cyhoeddwyd: (2021)

Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.
gan: Lancaster, D, et al.
Cyhoeddwyd: (2004)

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors.
gan: Tian, Y, et al.
Cyhoeddwyd: (2011)

Biochemistry of the hypoxia-inducible factor hydroxylases
gan: Fiorini, G, et al.
Cyhoeddwyd: (2024)

Promotion of chondrocyte function by inhibition of HIF-specific hydroxylases
gan: Thoms, B, et al.
Cyhoeddwyd: (2010)

Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model
gan: Singh, A, et al.
Cyhoeddwyd: (2020)

miR-190 Enhances HIF-Dependent Responses to Hypoxia in Drosophila by Inhibiting the Prolyl-4-hydroxylase Fatiga.
gan: Ana Laura De Lella Ezcurra, et al.
Cyhoeddwyd: (2016-05-01)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.
gan: Chen, R, et al.
Cyhoeddwyd: (2014)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice
gan: Chen, R, et al.
Cyhoeddwyd: (2014)

Inhibition of the oxygen-sensing asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor: a potential hypoxia response modulating strategy
gan: Wu, Y, et al.
Cyhoeddwyd: (2021)

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.
gan: Elkins, J, et al.
Cyhoeddwyd: (2003)

Collagen Prolyl Hydroxylases Are Bifunctional Growth Regulators in Melanoma
gan: Atkinson, Aithne, et al.
Cyhoeddwyd: (2020)

Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses
gan: Moritz J. Strowitzki, et al.
Cyhoeddwyd: (2021-04-01)

Oxygen sensing by HIF hydroxylases.
gan: Schofield, C, et al.
Cyhoeddwyd: (2004)

Regulation of HIF: prolyl hydroxylases.
gan: Stolze, I, et al.
Cyhoeddwyd: (2006)

Therapeutic manipulation of the HIF hydroxylases.
gan: Nagel, S, et al.
Cyhoeddwyd: (2010)

Functional variation in the hypoxia-inducible factor (HIF) pathway in humans
gan: Petousi, N
Cyhoeddwyd: (2012)

Metabolite and protein shifts in mature erythrocyte under hypoxia
gan: Xu Jin, et al.
Cyhoeddwyd: (2024-04-01)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
gan: Schlemminger, I, et al.
Cyhoeddwyd: (2003)

From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway.
gan: Ratcliffe, P
Cyhoeddwyd: (2002)

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates.
gan: Hewitson, K, et al.
Cyhoeddwyd: (2007)

Exploring the natural products chemical space through a molecular search to discover potential inhibitors that target the hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD)
gan: Abrar Mohammad Sayaf, et al.
Cyhoeddwyd: (2023-08-01)

Structural and mechanistic studies on prolyl hydroxylases
gan: Chowdhury, R
Cyhoeddwyd: (2008)

HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury
gan: Andrew N. Billin, et al.
Cyhoeddwyd: (2018-11-01)