The structural basis of ZMPSTE24-dependent laminopathies.

The structural basis of ZMPSTE24-dependent laminopathies.

Show other versions (1)

Mutations in the nuclear membrane zinc metalloprotease ZMPSTE24 lead to diseases of lamin processing (laminopathies), such as the premature aging disease progeria and metabolic disorders. ZMPSTE24 processes prelamin A, a component of the nuclear lamina intermediate filaments, by cleaving it at two s...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Quigley, A, Dong, Y, Pike, A, Dong, L, Shrestha, L, Berridge, G, Stansfeld, P, Sansom, MS, Edwards, A, Bountra, C, von Delft, F, Bullock, A, Burgess-Brown, N, Carpenter, E
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2013

Eitemau Tebyg

The structural basis of ZMPSTE24-dependent laminopathies
gan: Quigley, A, et al.
Cyhoeddwyd: (2013)

Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24
gan: Mehmood, S, et al.
Cyhoeddwyd: (2016)

Prelamin A and ZMPSTE24 in premature and physiological aging
gan: Howard J. Worman, et al.
Cyhoeddwyd: (2023-12-01)

ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA
gan: Moritz Messner, et al.
Cyhoeddwyd: (2020-08-01)

Requirements for efficient proteolytic cleavage of prelamin A by ZMPSTE24.
gan: Jemima Barrowman, et al.
Cyhoeddwyd: (2012-01-01)

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.
gan: Shintre, C, et al.
Cyhoeddwyd: (2013)

ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability
gan: Spear, ED, et al.
Cyhoeddwyd: (2018)

ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability
gan: Eric D. Spear, et al.
Cyhoeddwyd: (2018-07-01)

Deciphering Nuclear Mechanobiology in Laminopathy
gan: Jungwon Hah, et al.
Cyhoeddwyd: (2019-03-01)

运用二代测序技术产前诊断ZMPSTE24基因突变
gan: 麦明琴, et al.
Cyhoeddwyd: (2017-01-01)

The Senolytic Drug Fisetin Attenuates Bone Degeneration in the Zmpste24−/− Progeria Mouse Model
gan: William S. Hambright, et al.
Cyhoeddwyd: (2023-01-01)

Targeting CK2 eliminates senescent cells and prolongs lifespan in Zmpste24-deficient mice
gan: Jie Zhang, et al.
Cyhoeddwyd: (2024-05-01)

Inhibition of Arenavirus Entry and Replication by the Cell-Intrinsic Restriction Factor ZMPSTE24 Is Enhanced by IFITM Antiviral Activity
gan: Robert J. Stott-Marshall, et al.
Cyhoeddwyd: (2022-02-01)

Defining substrate requirements for cleavage of farnesylated prelamin A by the integral membrane zinc metalloprotease ZMPSTE24.
gan: Kaitlin M Wood, et al.
Cyhoeddwyd: (2020-01-01)

Clinical and genetic characteristics of hereditary laminopathies
gan: E. L. Dadaly, et al.
Cyhoeddwyd: (2017-02-01)

Clinical and diagnostic difficulties in management of patients with laminopathies
gan: O. V. Melnik, et al.
Cyhoeddwyd: (2019-11-01)

Accelerated aging in articular cartilage by ZMPSTE24 deficiency leads to osteoarthritis with impaired metabolic signaling and epigenetic regulation
gan: Jinlong Suo, et al.
Cyhoeddwyd: (2023-05-01)

A Heterozygous ZMPSTE24 Mutation Associated with Severe Metabolic Syndrome, Ectopic Fat Accumulation, and Dilated Cardiomyopathy
gan: Damien Galant, et al.
Cyhoeddwyd: (2016-04-01)

Deficiency in ZMPSTE24 and resulting farnesyl–prelamin A accumulation only modestly affect mouse adipose tissue stores[S]
gan: Patrick J. Heizer, et al.
Cyhoeddwyd: (2020-03-01)

Cellular and Animal Models of Striated Muscle Laminopathies
gan: Hannah A. Nicolas, et al.
Cyhoeddwyd: (2019-03-01)

AN ORPHAN PHENOTYPE OF CARDIOGENITAL LAMINOPATHY — MALOUF SYNDROME
gan: T. G. Vaykhanskaya, et al.
Cyhoeddwyd: (2016-11-01)

Restrictive Dermopathy Due to ZMPSTE24 Mutation: A Case Report with a Novel Finding of Corpus Callosum Agenesis
gan: Minu Jose Chiramel, et al.
Cyhoeddwyd: (2024-01-01)

Lamin A/C Mechanotransduction in Laminopathies
gan: Francesca Donnaloja, et al.
Cyhoeddwyd: (2020-05-01)

Nuclear damages and oxidative stress: new perspectives for laminopathies
gan: G. Lattanzi, et al.
Cyhoeddwyd: (2012-10-01)

Structural basis for ASPP2 recognition by the tumor suppressor p73
gan: Canning, P, et al.
Cyhoeddwyd: (2012)

Structural basis for ASPP2 recognition by the tumor suppressor p73.
gan: Canning, P, et al.
Cyhoeddwyd: (2012)

Cardiac involvement in laminopathies – short invited review
gan: Gerardo Nigro, et al.
Cyhoeddwyd: (2015-12-01)

Implications and Assessment of the Elastic Behavior of Lamins in Laminopathies
gan: Subarna Dutta, et al.
Cyhoeddwyd: (2016-10-01)

Inflammatory myopathy in the context of an unusual overlapping laminopathy
gan: Cristina Guillín-Amarelle, et al.
Cyhoeddwyd: (2018-05-01)

The empowerment of translational research: lessons from laminopathies
gan: Benedetti Sara, et al.
Cyhoeddwyd: (2012-06-01)

HIV protease inhibitors inhibit FACE1/ZMPSTE24: a mechanism for acquired lipodystrophy in patients on highly active antiretroviral therapy?
gan: Goulbourne, C, et al.
Cyhoeddwyd: (2010)

Simulations of the BM2 proton channel transmembrane domain from influenza virus B.
gan: Rouse, S, et al.
Cyhoeddwyd: (2009)

Embryonic Senescence and Laminopathies in a Progeroid Zebrafish Model
gan: Koshimizu, Eriko, et al.
Cyhoeddwyd: (2011)

Embryonic senescence and laminopathies in a progeroid zebrafish model.
gan: Eriko Koshimizu, et al.
Cyhoeddwyd: (2011-03-01)

Risk stratification in laminopathies and Emery Dreifuss muscular dystrophy
gan: Abdallah Fayssoil
Cyhoeddwyd: (2018-04-01)

Emery-Dreifuss muscular dystrophy: the most recognizable laminopathy
gan: Agnieszka Madej-Pilarczyk, et al.
Cyhoeddwyd: (2016-03-01)

Aberrant chromatin organization at the nexus of laminopathy disease pathways
gan: Garrett T. Santini, et al.
Cyhoeddwyd: (2022-12-01)

The farnesyl transferase inhibitor (FTI) lonafarnib improves nuclear morphology in ZMPSTE24-deficient fibroblasts from patients with the progeroid disorder MAD-B
gan: Kamsi O. Odinammadu, et al.
Cyhoeddwyd: (2023-12-01)

The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation
gan: Khurts Shilagardi, et al.
Cyhoeddwyd: (2022-10-01)

Nuclear envelope proteins and chromatin arrangement: a pathogenic mechanism for laminopathies
gan: NM Maraldi, et al.
Cyhoeddwyd: (2009-06-01)