Modelling the ATP binding site of RyR2 to rationalise ligand-induced gating behaviour

Eitemau Tebyg

• Promiscuous attraction of ligands within the ATP binding site of RyR2 promotes diverse gating behaviour
  gan: Lindsay, C, et al.
  Cyhoeddwyd: (2018)
• Statins bind to cardiac ryanodine receptor (RyR2) channels to alter opening frequency
  gan: Wilson, A, et al.
  Cyhoeddwyd: (2018)
• Impaired ligand regulation of native RyR2 channels in the catecholaminergic polymorphic ventricular tachycardia mutation, RyR2-V2475F(+/−)
  gan: Wilson, A, et al.
  Cyhoeddwyd: (2019)
• Atorvastatin activates skeletal RyR1 channels: towards reducing statin side-effects
  gan: Lindsay, C, et al.
  Cyhoeddwyd: (2018)
• Ca2+-calmodulin increases RyR2 open probability yet reduces ryanoid association with RyR2
  gan: Sigalas, C, et al.
  Cyhoeddwyd: (2009)