Chronic hepatitis C viral infection subverts vaccine-induced T-cell immunity in humans

Chronic hepatitis C viral infection subverts vaccine-induced T-cell immunity in humans

Adenoviral vectors encoding hepatitis C virus (HCV) nonstructural (NS) proteins induce multispecific, high-magnitude, durable CD4+ and CD8+ T-cell responses in healthy volunteers. We assessed the capacity of these vaccines to induce functional HCV-specific immune responses and determine T-cell cross...

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Bibliographic Details
Main Authors: Kelly, C, Swadling, L, Capone, S, Brown, A, Richardson, R, Halliday, J, von Delft, A, Oo, Y, Mutimer, D, Kurioka, A, Hartnell, F, Collier, J, Ammendola, V, Sorbo, M, Grazioli, F, Esposito, M, Marco, S, Siani, L, Traboni, C, Hill, A, Colloca, S, Nicosia, A, Cortese, R, Folgori, A, Klenerman, P, Barnes, E
Format: Journal article
Language:English
Published: Wiley 2016

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