EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.

The BRCA2 gene is mutated in familial breast and ovarian cancer, and its product is implicated in DNA repair and transcriptional regulation. Here we identify a protein, EMSY, which binds BRCA2 within a region (exon 3) deleted in cancer. EMSY is capable of silencing the activation potential of BRCA2...

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Bibliographic Details
Main Authors:	Hughes-Davies, L, Huntsman, D, Ruas, M, Fuks, F, Bye, J, Chin, S, Milner, J, Brown, L, Hsu, F, Gilks, B, Nielsen, T, Schulzer, M, Chia, S, Ragaz, J, Cahn, A, Linger, L, Ozdag, H, Cattaneo, E, Jordanova, E, Schuuring, E, Yu, D, Venkitaraman, A, Ponder, B, Doherty, A, Aparicio, S
Format:	Journal article
Language:	English
Published:	2003

EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.

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