A novel method to adjust efficacy estimates for uptake of other active treatments in long-term clinical trials.

BACKGROUND: When rates of uptake of other drugs differ between treatment arms in long-term trials, the true benefit or harm of the treatment may be underestimated. Methods to allow for such contamination have often been limited by failing to preserve the randomization comparisons. In the Fenofibrat...

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Bibliographic Details
Main Authors: Simes, J, Voysey, M, O'Connell, R, Glasziou, P, Best, J, Scott, R, Pardy, C, Byth, K, Sullivan, DR, Ehnholm, C, Keech, A
Format: Journal article
Language:English
Published: 2010