A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease
Alzheimer's disease (AD) involves progressive accumulation of amyloid β-peptide (Aβ) and neurofibrillary pathologies, and glucose hypometabolism in brain regions critical for memory. The 3xTgAD mouse model was used to test the hypothesis that a ketone ester-based diet can ameliorate AD pathogen...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
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2013
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| _version_ | 1826263871003820032 |
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| author | Kashiwaya, Y Bergman, C Lee, J Wan, R King, M Mughal, MR Okun, E Clarke, K Mattson, M Veech, R |
| author_facet | Kashiwaya, Y Bergman, C Lee, J Wan, R King, M Mughal, MR Okun, E Clarke, K Mattson, M Veech, R |
| author_sort | Kashiwaya, Y |
| collection | OXFORD |
| description | Alzheimer's disease (AD) involves progressive accumulation of amyloid β-peptide (Aβ) and neurofibrillary pathologies, and glucose hypometabolism in brain regions critical for memory. The 3xTgAD mouse model was used to test the hypothesis that a ketone ester-based diet can ameliorate AD pathogenesis. Beginning at a presymptomatic age, 2 groups of male 3xTgAD mice were fed a diet containing a physiological enantiomeric precursor of ketone bodies (KET) or an isocaloric carbohydrate diet. The results of behavioral tests performed at 4 and 7 months after diet initiation revealed that KET-fed mice exhibited significantly less anxiety in 2 different tests. 3xTgAD mice on the KET diet also exhibited significant, albeit relatively subtle, improvements in performance on learning and memory tests. Immunohistochemical analyses revealed that KET-fed mice exhibited decreased Aβ deposition in the subiculum, CA1 and CA3 regions of the hippocampus, and the amygdala. KET-fed mice exhibited reduced levels of hyperphosphorylated tau deposition in the same regions of the hippocampus, amygdala, and cortex. Thus, a novel ketone ester can ameliorate proteopathic and behavioral deficits in a mouse AD model. © 2013 . |
| first_indexed | 2024-03-06T19:58:45Z |
| format | Journal article |
| id | oxford-uuid:268ae7a0-28e6-4155-bc50-41d52d24f858 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T19:58:45Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:268ae7a0-28e6-4155-bc50-41d52d24f8582022-03-26T12:01:36ZA ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:268ae7a0-28e6-4155-bc50-41d52d24f858Symplectic Elements at Oxford2013Kashiwaya, YBergman, CLee, JWan, RKing, MMughal, MROkun, EClarke, KMattson, MVeech, RAlzheimer's disease (AD) involves progressive accumulation of amyloid β-peptide (Aβ) and neurofibrillary pathologies, and glucose hypometabolism in brain regions critical for memory. The 3xTgAD mouse model was used to test the hypothesis that a ketone ester-based diet can ameliorate AD pathogenesis. Beginning at a presymptomatic age, 2 groups of male 3xTgAD mice were fed a diet containing a physiological enantiomeric precursor of ketone bodies (KET) or an isocaloric carbohydrate diet. The results of behavioral tests performed at 4 and 7 months after diet initiation revealed that KET-fed mice exhibited significantly less anxiety in 2 different tests. 3xTgAD mice on the KET diet also exhibited significant, albeit relatively subtle, improvements in performance on learning and memory tests. Immunohistochemical analyses revealed that KET-fed mice exhibited decreased Aβ deposition in the subiculum, CA1 and CA3 regions of the hippocampus, and the amygdala. KET-fed mice exhibited reduced levels of hyperphosphorylated tau deposition in the same regions of the hippocampus, amygdala, and cortex. Thus, a novel ketone ester can ameliorate proteopathic and behavioral deficits in a mouse AD model. © 2013 . |
| spellingShingle | Kashiwaya, Y Bergman, C Lee, J Wan, R King, M Mughal, MR Okun, E Clarke, K Mattson, M Veech, R A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease |
| title | A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease |
| title_full | A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease |
| title_fullStr | A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease |
| title_full_unstemmed | A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease |
| title_short | A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease |
| title_sort | ketone ester diet exhibits anxiolytic and cognition sparing properties and lessens amyloid and tau pathologies in a mouse model of alzheimer s disease |
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