Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE.
The cytokine tumor necrosis factor (TNF) is the primary trigger of inflammation. Like many extracellular signaling proteins, TNF is synthesized as a transmembrane protein; the active signal is its ectodomain, which is shed from cells after cleavage by an ADAM family metalloprotease, ADAM17 (TNFα-con...
| Hauptverfasser: | , , , , |
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| Format: | Journal article |
| Sprache: | English |
| Veröffentlicht: |
2012
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