Nuclear beta-catenin expression and Wnt signalling: in defence of the dogma.
Inactivation of the APC tumour suppressor gene represents the rate-limiting event in colorectal cancer. Loss of APC function leads to constitutive activation of the canonical Wnt-beta-catenin signalling pathway, thus resulting into a broad spectrum of cellular defects, ranging from stem cell self-re...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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