Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism
The core machinery for de novo biosynthesis of iron-sulfur clusters (ISC), located in the mitochondria matrix, is a five-protein complex containing the cysteine desulfurase NFS1 that is activated by frataxin (FXN), scaffold protein ISCU, accessory protein ISD11, and acyl-carrier protein ACP. Deficie...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Sprog: | English |
| Udgivet: |
Springer Nature
2019
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