Improving SRM assay development: a global comparison between triple quadrupole, ion trap, and higher energy CID peptide fragmentation spectra.

In proteomics, selected reaction monitoring (SRM) is rapidly gaining importance for targeted protein quantification. The triple quadrupole mass analyzers used in SRM assays allow for levels of specificity and sensitivity hard to accomplish by more standard shotgun proteomics experiments. Often, an S...

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Bibliographic Details
Main Authors: de Graaf, E, Altelaar, A, van Breukelen, B, Mohammed, S, Heck, A
Format: Journal article
Language:English
Published: 2011