A prospective, blinded analysis of thymidylate synthase and p53 expression as prognostic markers in the adjuvant treatment of colorectal cancer.

BACKGROUND: Despite previous studies, uncertainty has persisted about the role of thymidylate synthase (TS) and p53 status as markers of prognosis in colorectal cancer (CRC). PATIENTS AND METHODS: A total of 967 patients accrued to a large adjuvant trial in CRC were included in a prospectively plan...

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Bibliographic Details
Main Authors: Popat, S, Chen, Z, Zhao, D, Pan, H, Hearle, N, Chandler, I, Shao, Y, Aherne, W, Houlston, R
Format: Journal article
Language:English
Published: 2006