Anticancer DNA intercalators cause p53-dependent mitochondrial DNA nucleoid re-modelling.

Anticancer DNA intercalators cause p53-dependent mitochondrial DNA nucleoid re-modelling.

Many anticancer drugs, such as doxorubicin (DXR), intercalate into nuclear DNA of cancer cells, thereby inhibiting their growth. However, it is not well understood how such drugs interact with mitochondrial DNA (mtDNA). Using cell and molecular studies of cultured cells, we show that DXR and other D...

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Dettagli Bibliografici
Autori principali:	Ashley, N, Poulton, J
Natura:	Journal article
Lingua:	English
Pubblicazione:	2009

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