Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous.

Mice deficient for the expression of CTLA-4 develop a lethal lymphoproliferative syndrome and multiorgan inflammation leading to death at about 4 wk of age. Here we show that RAG2-deficient mice reconstituted with CTLA-4-deficient bone marrow do not develop a lymphoproliferative syndrome despite lym...

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Bibliographic Details
Main Authors: Bachmann, M, Köhler, G, Ecabert, B, Mak, T, Kopf, M
Format: Journal article
Language:English
Published: 1999