Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous.
Mice deficient for the expression of CTLA-4 develop a lethal lymphoproliferative syndrome and multiorgan inflammation leading to death at about 4 wk of age. Here we show that RAG2-deficient mice reconstituted with CTLA-4-deficient bone marrow do not develop a lymphoproliferative syndrome despite lym...
Main Authors: | , , , , |
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Format: | Journal article |
Language: | English |
Published: |
1999
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