Modulation of triple artemisinin-based combination therapy pharmacodynamics by Plasmodium falciparum genotype

The first-line treatments for uncomplicated Plasmodium falciparum malaria are artemisinin-based combination therapies (ACTs), consisting of an artemisinin derivative combined with a longer acting partner drug. However, the spread of P. falciparum with decreased susceptibility to artemisinin and part...

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Bibliographic Details
Main Authors: Ansbro, MR, Itkin, Z, Chen, L, Zahoranszky-Kohalmi, G, Amaratunga, C, Miotto, O, Peryea, T, Hobbs, CV, Suon, S, Sá, JM, Dondorp, AM, van der Pluijm, RW, Wellems, TE, Simeonov, A, Eastman, RT
Format: Journal article
Language:English
Published: American Chemical Society 2020