K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

TREK-2 (KCNK10/K2P10), a two-pore domain potassium (K2P) channel, is gated by multiple stimuli such as stretch, fatty acids, and pH and by several drugs. However, the mechanisms that control channel gating are unclear. Here we present crystal structures of the human TREK-2 channel (up to 3.4 angstro...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs:	Dong, Y, Pike, A, Mackenzie, A, McClenaghan, C, Aryal, P, Dong, L, Quigley, A, Grieben, M, Goubin, S, Mukhopadhyay, S, Ruda, G, Clausen, M, Cao, L, Brennan, P, Burgess-Brown, N, Sansom, M, Tucker, S, Carpenter, E
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	American Association for the Advancement of Science 2015

Gelijkaardige items

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.
door: Aryal, P, et al.
Gepubliceerd in: (2017)

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.
door: McClenaghan, C, et al.
Gepubliceerd in: (2016)

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.
door: McClenaghan, C, et al.
Gepubliceerd in: (2016)

Investigations into the structure, function and pharmacology of TREK K2P potassium channels
door: McClenaghan, C
Gepubliceerd in: (2015)

The effects of stretch activation on ionic selectivity of the TREK-2 K2P K(+) channel
door: Nematian-Ardestani, E, et al.
Gepubliceerd in: (2017)

Prozac diary /
door: 531444 Slater, Lauren
Gepubliceerd in: (1999)

Prozac talks back
door: Cipriani, A
Gepubliceerd in: (2016)

Prozac nation : young and depressed in America /
door: Wurtzel, Elizabeth
Gepubliceerd in: (c200)

Prozac and the new antidepressants : what you need to know about prozac, zoloft, paxil, luvox, wellbutrin, effexor, serzone, and more /
door: 329420 Appleton, William S.
Gepubliceerd in: (1997)

Lipid interactions of a ciliary membrane TRP channel: simulation and structural studies of Polycystin-2 (PC2)
door: Wang, Q, et al.
Gepubliceerd in: (2019)

Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation
door: Rödström, KEJ, et al.
Gepubliceerd in: (2024)

State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1.
door: Rapedius, M, et al.
Gepubliceerd in: (2012)

« Le Prozac est la meilleure de toutes les inventions »
door: Angel Martinez Hernaez
Gepubliceerd in: (2007-11-01)

Effects of ionic strength on gating and permeation of TREK-2 K2P channels
door: Conrad, LJ, et al.
Gepubliceerd in: (2021)

Transition between conformational states of the TREK-1 K2P channel promoted by interaction with PIP2
door: Panasawatwong, A, et al.
Gepubliceerd in: (2022)

Tension activation of mechanosensitive two-pore domain K+ channels TRAAK, TREK-1, and TREK-2
door: Ben Sorum, et al.
Gepubliceerd in: (2024-04-01)

Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate
door: Proks, P, et al.
Gepubliceerd in: (2021)

Effects of ionic strength on gating and permeation of TREK-2 K2P channels.
door: Linus J Conrad, et al.
Gepubliceerd in: (2021-01-01)

Trek.
door: Lenelle Foster
Gepubliceerd in: (2017-03-01)

Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation
door: Karin E. J. Rödström, et al.
Gepubliceerd in: (2024-05-01)

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)
door: Grieben, M, et al.
Gepubliceerd in: (2016)

The antidepressant fluoxetine (Prozac®) modulates serotonin signaling to alter maternal peripartum calcium homeostasis
door: Rafael R. Domingues, et al.
Gepubliceerd in: (2023-12-01)

Mens prozac in corpore xanax: as hesitações da responsabilidade subjetiva nos eua hoje
door: Patricia Gherovici
Gepubliceerd in: (1997-12-01)

Prozac Alters Reproductive Performance and Filial Cannibalism in Male Fighting Fish, Betta Splendens
door: Mohammad Navid Forsatkar, et al.
Gepubliceerd in: (2014-09-01)

Nature's prozac: natural therapies and techniques to rid yourself of anxiety, depression, panic attacks & stress /
door: 339629 Sachs, Judith
Gepubliceerd in: (1997)

Prozac para zombies. La sentimentalización contemporánea del muerto viviente en la televisión
door: Alberto Nahum García Martínez
Gepubliceerd in: (2016-06-01)

β-COP Suppresses the Surface Expression of the TREK2
door: Seong-Seop Kim, et al.
Gepubliceerd in: (2023-05-01)

2-Aminoethoxydiphenyl borate activates the human mechano-gated KCNK channels KCNK 2 (TREK-1), KCNK 4 (TRAAK) and KCNK 10 (TREK-2).
door: Leopoldo Raul Beltran, et al.
Gepubliceerd in: (2013-05-01)

Are TREK Channels Temperature Sensors?
door: Lola Rueda-Ruzafa, et al.
Gepubliceerd in: (2021-10-01)

Star trek [videorecording] /
door: Abrams, Jeffrey, 1964-, et al.
Gepubliceerd in: (2009)

Twenty years after ‘Listening to Prozac but hearing placebo’. Do we hear placebo even louder?
door: Wojciech Oronowicz-Jaśkowiak, et al.
Gepubliceerd in: (2019-03-01)

K2P and Kir K+ Channels in Physiological Bilayers
door: Schmidt, MR, et al.
Gepubliceerd in: (2013)

2. La Plataforma d'Afectats per la Hipoteca. De la Crisi a la Estafa. Del Prozac al Empoderament
door: Lluís Mangot
Gepubliceerd in: (2014-02-01)

The Prostacyclin Analogue, Treprostinil, Used in the Treatment of Pulmonary Arterial Hypertension, is a Potent Antagonist of TREK-1 and TREK-2 Potassium Channels
door: Kevin P. Cunningham, et al.
Gepubliceerd in: (2021-06-01)

Does bilateral otosclerosis make pre-operative bone conduction more inaccurate?
door: Fiona McClenaghan, et al.
Gepubliceerd in: (2021-01-01)

The Modified Stenver’s View for Cochlear Implants – What do the Surgeons Want to Know?
door: Fiona McClenaghan, et al.
Gepubliceerd in: (2020-07-01)

Vasoactive agents in acute mesenteric ischaemia in critical care. A systematic review [version 2; peer review: 1 approved, 2 approved with reservations]
door: Christopher A Brennan, et al.
Gepubliceerd in: (2021-09-01)

Asymmetric mechanosensitivity in a eukaryotic ion channel
door: Clausen, M, et al.
Gepubliceerd in: (2017)

Characterization of temperature-sensitive leak K+ currents and expression of TRAAK, TREK-1, and TREK2 channels in dorsal root ganglion neurons of rats
door: Viacheslav Viatchenko-Karpinski, et al.
Gepubliceerd in: (2018-07-01)

Discovery excels in demanding trek.
door: 324948 Symes, Alan author
Gepubliceerd in: (1999)